ALCAR: NEUROPROTECTION & REGENERATION
ALCAR (Acetyl L-Carnitine) is a derivative of the common workout supplement L-carnitine and is naturally produced in the body. ALCAR is known to be more effective than L-carnitine because it is more bioavailable and is able to pass through the blood-brain barrier. Acetyl-L-Carnitine binds with choline in the brain to produce acetylcholine, a neurotransmitter responsible for memory. ALCAR is a powerful antioxidant. Pharmacological indicate that ALCAR protects against oxidative stress which is defined as an imbalance between free radicals and the body’s ability to counteract their harmful effects. Oxidative stress causes brain damage, strand breaks in DNA, and is involved in the development of cancer, ADHD, heart failure, depression, autism, Parkinson’s disease, etc. ALCAR can be used to combat oxidative stress. ALCAR also helps prevent ATP depletion, ATP being the main energy source for cellular function. Several studies show ALCAR’s neuroprotective and neuroregenerative abilities. ALCAR supplementation at low levels (50 or 100mg/kg) improve energy metabolism and antioxidative abilities. ALCAR also has rapid-acting antidepressent effects and may decrease the risk of age-related diseases.
Aniracetam is a nootropic in the Racetam family, a class of synthetic compounds known for increasing cognition, alertness, memory, and other brain functions. Aniracetam is 10 times more potent than the parent racetam, piracetam. Pharmacological studies on mice suggest aniracetam as a useful compound for combating anxiety, anxiety-related disorder, and social failure/impairments. Aniracetam’s anxiolytic effects are thought to be due to interaction between cholinergic, dopaminergic, and serotonergic systems. Aniracetam increases extracellular levels of dopamine and serotonin in the prefrontal cortex, amygdala and hippocampus. As a facilitator of dopamingeric transmission, Aniracetam also has reported antidepressant like effects. Aniracetam increases cognition and aids in emotional stability.
Artichoke (Cynara) is a wild plant mainly native to the Mediterranean region. There are records of consumption of artichoke in ancient Greece and Rome. Our artichoke extract is an organic 10% cynarin extract, making it much more potent than eating raw artichoke. An active ingredient in artichoke, luteolin, is known to as a protective agent for preventing learning defects. Research also shows that luteolin can be beneficial for treating and preventing brain disorders from excitotoxic brain damage and can improve memory. Exciotoxicity may be involved in Alzheimer’s disease, multiple sclerosis, neurodegenerative diseases, stroke, hearing loss, alcohol withdrawal, benzodiazepine withdrawal, hypoglycemia, etc. Artichoke promotes blood flow and may reduce the risk of developing cardiovascular complications. Cyanarin is an antioxidant an may stimulate bile secretion, possibly aiding in reduction of cholesterol and an improvement in fat digestion.
Coleus Forskholii (Plectranthus Barbatus) is a member of the mint family used in Ayurvedic medicine in India. We use a 20% forskolin extract, a diterpenoid found only in the Coleus Forskohlii plant. Diterpenoids are often used as chemotherapy agents, are are known to be antiinflammatory and antimicrobial. Forskolin increases cellular levels of cAMP, which can lead to memory improvement. Many people report energy boosting and an increase in cognitive processing from the combination of forskolin and artichoke extract, although this has not been studied extensively. Medical research also suggests foskolin may be useful in the treatment of heart failure, glaucoma, asthma, and certain types of cancer. Flavanoids present in forskolin indicate its antioxidant properties. Forskolin significantly increases levels of serum free testosterone and may be used in the treatment of obesity.
5. Wang W, Lu Y, Xue Z, Li C, Wang C, Zhao X, Zhang J, Wei X, Chen X, Cui W, Wang Q, Zhou W. Rapid-acting antidepressant-like effects of acetyl-l-carnitine mediated by PI3K/AKT/BDNF/VGF signaling pathway in mice. 2015.
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